InquiryIntegrated Analysis of Spatial Transcriptomics and Proteomics
Spatial transcriptomics and proteomics are two important areas of study in molecular biology and cellular biology. While transcriptomics focuses on the analysis of RNA expression patterns, proteomics focuses on the analysis of protein expression and function.
Spatial transcriptomics involves the mapping of gene expression across a tissue sample, providing information about the relative abundance and localization of transcripts in different regions of the tissue. This information is valuable for understanding the molecular basis of tissue organization and function, as well as for the discovery of new biomarkers and therapeutic targets.
Proteomics, on the other hand, provides information about the abundance, localization, and modifications of proteins in a tissue sample. This information is important for understanding the functional role of proteins in a tissue and how they interact with other proteins and cellular components.
When integrated, spatial transcriptomics and proteomics can provide a more comprehensive view of cellular processes and molecular interactions. For example, they can be used to identify novel molecular mechanisms and disease biomarkers, as well as to study the functional relationships between genes and proteins.
Both spatial transcriptomics and proteomics are advancing rapidly, and new technologies are being developed to increase their speed, accuracy, and resolution. These advances are allowing researchers to study molecular biology in greater detail and to gain a deeper understanding of cellular processes.
In conclusion, the integration of spatial transcriptomics and proteomics provides a powerful tool for the study of cellular biology and has the potential to impact numerous areas of biological research and medicine.
Our Integrates Spatial Transcriptomics and Proteomics Solution
The Visium Spatial Transcriptome-Combined Proteomics Solution detects the entire transcriptome or a specified set of transcripts in intact tissue sections and maps where gene activity occurs. With whole-transcriptome analysis, you can explore and reveal the spatial arrangement of cell types, cell states, and biomarkers. You can also focus on specific genes or pathways of interest with our predesigned oncology, immunology or neuroscience targeted gene panels. Combined with immunofluorescence, you can visualize protein and gene expression simultaneously. The Visium Spatial Gene Expression Solution easily integrates spatial transcriptomics technology into standard tissue sections as well as H&E staining or immunofluorescence staining methods. Now you can finally analyze tissue sections from the perspective of RNA, protein, and morphology in the same sample through simple, complementary workflows.
Highlights:
- Discover new tissue biomarkers by analyzing histology, protein and mRNA from the same tissue section
- Uncover the spatial arrangement of newly discovered cell types, cell states, and biomarkers through transcriptome-wide analysis
- Use predesigned panels of targeted genes to validate previous findings or focus on all relevant genes
- Elucidate biological structures and understand spatial relationships between cells in normal and diseased tissues
- Analyze and understand gene and protein expression heterogeneity and its contribution to the system
Features:
- Easily integrates with your lab's existing tissue analysis methods and tools, allowing you to immediately perform spatial gene expression experiments
- No need to dissociate samples prior to gene expression studies to preserve spatial context
- Extend your analysis beyond pre-defined regions of interest, allowing you to analyze entire tissue sections at once without missing unexpected results
- Combine immunofluorescent staining with imaging to enable multi-omic identification in spatial context
- Combined with targeted gene expression solutions, you can focus on the most important genes and accelerate research to valuable discoveries
