InquirySingle-cell sequencing has allowed us to understand the complex mixture of cell types present in different tissues. We have even discovered new cell types that were not previously known. However, because cells are dissociated, single-cell sequencing cannot provide information about the location of each cell in the intact tissue. In contrast, combining spatial information on top of single-cell resolution adds additional spatial information to that provided by single-cell sequencing methods. This can thus be used as a key breakthrough point for drug discovery.
We provide spatial omics technology support at multiple stages of drug development
Developing therapeutics for complex diseases requires a comprehensive understanding of disease and therapeutic response mechanisms, from single cells to tissue spatial structure, etc. CD Genomics offers spatial biology services that enable comprehensive phenotypic immunoassays, tissue structure characterization, tumor heterogeneity investigation, and biomarker expression assessment on whole slide samples. Highly multiplexable tissue analysis is available for biopharmaceutical partners and translational medicine researchers.
Figure 1. Information layers obtained from cell-based assays. (Daniel, S., et al., 2022)
- Target identification. We identify and maintain new drug development targets through high-throughput screening at single-cell resolution, providing you with more information to accelerate the identification and hitting of potential targets.
- Target validation. Identify subpopulations of cells that respond to therapy and decipher the molecular mechanisms of action that control therapeutic response and drug resistance. Targeted advancement of drug development.
- Translational studies. Effectively stratify disease populations through detailed multi-omics dataset analysis. Leverage valuable clinical samples to better obtain large amounts of data from each cell.
Sample types that can be analyzed: fresh frozen tissue samples (FFPE compatible samples)
Technical features and advantages
- Spatial analysis of gene expression in intact FFPE or fresh frozen tissue sections using morphological background.
- Scan experimental samples multiple times to discover new data that help explain drug resistance or disease recurrence, refine pathology annotation and explore tumor heterogeneity in a morphological context.
- Map the entire transcriptome in FFPE or fresh frozen tissue with morphological context to discover new insights into normal development, disease pathology, and clinical translational studies.
- Classify tissues based on total mRNA to customize rare cell analysis for drug targeting and research.
We do it better
CD Genomics offers spatial biology services that enable comprehensive analysis and evaluation of entire samples to fully understand the complexity of the disease and decipher the molecular mechanisms of action that control therapeutic response and drug resistance. To spatially map global gene expression through whole transcriptome analysis and identify the expression patterns of genes across space and time. Or use the targeted gene expression panel to focus on your genes of interest to discover novel biomarkers that can assist our clients in targeted drug development.
Reference
- Daniel, S., et al., (2022). "Capturing the third dimension in drug discovery: Spatially-resolved tools for interrogation of complex 3D cell models." Biotechnology Advances. 55, 107883.
