InquirySingle-cell flow cytometry and genomic approaches are rapidly increasing researchers' understanding of the diversity of cell types in animal tissues. Placing target cells in a spatial context to reveal their localization and putative interactions for use in facilitating tissue physiology and pathology studies is also an important part of this process.
We offer multi-parametric imaging analysis services
The diverse composition of animal tissues is a great challenge for researchers to understand cell-cell interactions as well as spatial relationships during disease. CD Genomics integrates multiple imaging techniques of immunohistochemistry (IHC), immunofluorescence (IF), fluorescence in situ hybridization (FISH), multiplexed ion beam imaging (MIBI), and imaging mass spectrometry flow (IMC) to form a unique, highly multiplexed spatial bioimaging analysis system that is sensitive, robust, high-throughput and compatible with standard tissue processing techniques.
Figure 1. Spatial bioimaging for precision cancer diagnostics at the single-cell and subcellular levels. (Allam M., et al., 2020)
The general process includes:
- Isolation of tissue
- Fixation
- Paraffin embedding
- Tissue sectioning
- Analysis of tissue samples by spatially resolved multi-parametric imaging systems
Our system allows for fine-grained analysis of cells in specific tissue environments for in-depth phenotypic, morphological, and tissue structural analysis. Researchers can use our platform to explore new questions in a wide range of research areas such as cancer, immunology, and neurobiology.
Features you can rely on
- Analyze all types of cell and tissue sample types.
- Multiple labeled signals can be presented simultaneously on a single section, enabling tissue microenvironment landscape analysis.
- Enables multi-parametric (＞60) high-resolution imaging in the same tissue section without physical degradation.
- Different cell types and their spatial localization relationships can be elucidated, and different biomarkers or intercellular interactions can be quantitatively depicted.
- High-speed scanning is also possible for rare cells and whole tissues and allows super-resolution imaging.
- Enables high-resolution and sensitive multiplexed imaging biopsies in human tissues.
Wide range of practical applications
- Aids in tumor immunology studies for immune cell phenotyping.
- Can be used to observe cell cycle characteristics, with DNA damage detection.
- Can be used for solid biopsies to understand the tissue microenvironment and analyze tumor composition.
- Can be used for liquid biopsies to capture and analyze circulating tumor cells (CTCs) and immune cells.
- Enables rapid monitoring of cancer progression at low cost.
- Can be applied to cell/gene therapy processes.
Reference
- Allam M., et al., (2020). "Multiplex bioimaging of single-cell spatial profiles for precision cancer diagnostics and therapeutics." npj Precision Oncology, 4, 11.
