Spatial Omics Solutions for Wnt/β-Catenin Signaling Pathway

The Wnt/β-catenin signaling pathway is essential for regulating cell proliferation and polarity, cellular decisions, and tissue homeostasis. It is a highly conserved pathway that regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal.

Overexpression of immune checkpoint molecules in the tumor microenvironment has a key role in antitumor immune evasion and cancer progression. The Wnt/β-catenin pathway has been identified as one of the important oncogenic pathway signaling associated with immune evasion. The Wnt/β-catenin pathway has also been implicated in the regulation of innate immunity.

How we use a spatial-omics approach to resolve the Wnt/β-catenin pathway

The Wnt/β-catenin pathway is intricately involved in the pathogenesis of several cancers and plays an important role in regulating immune cell infiltration in the tumor microenvironment. CD Genomics focuses on the physiological importance of the Wnt/β-catenin pathway in tumorigenesis. Moreover, crosstalk between Wnt/β-catenin and PI3K-Akt pathways has been shown to promote tumorigenesis and resistance to cancer therapy. Therefore, analysis of the Wnt/β-catenin pathway presents the potential for targeted drug development and therapy in preclinical studies and clinical trials for certain cancer types.

Figure 1. Wnt/β-catenin signaling mechanism. (Silva, G. O., et al., 2019)

We parse the advances and challenges of targeted interventions in malignancies by the Wnt/β-catenin signaling pathway to provide theoretical rationale and insights into new strategies for cancer therapy. And analyzing the role of Wnt/β-catenin inhibitors as possible adjuvants against PD1, anti-CTLA4 or anti-PD-L1 is a promising strategy that can be evaluated in preclinical and clinical studies.

Key genes that we offer our customers to study

Potential application areas

• Colorectal cancer (CRC)
• Non-colorectal cancer
• Sclerofibrosarcoma
• Breast cancer
• Adrenocortical tumors
• Melanoma
• Glioblastoma multiforme
• Renal cell carcinoma (RCC)
• Osteosarcoma
• Hematologic malignancies
• Infectious diseases

We do it better

The Wnt/β-catenin pathway is increasingly recognized as a potentially important target for anti-cancer therapies. CD Genomics can provide insight into the role of the Wnt/β-catenin pathway in cancer-related immune regulation with the help of spatial omics technologies that may provide a new dimension to this developing therapeutic area. To demonstrate the potential of the Wnt/β-catenin pathway in an individualized approach to the treatment of cancer patients.

Reference

1. Silva, G. O., et al., (2019). "Wnt/β-Catenin Signaling as a Molecular Target by Pathogenic Bacteria." Frontiers in Immunology. 10, 2135.