InquiryAutoimmune diseases are due to various causes of disruption of the body's immune regulation, mostly related to autoantibodies. The immune system is unable to distinguish between its specific cells and tissues, and both the immune tolerance mechanisms that recognize self/non-self are disrupted and cause a series of pathologies. Autoimmune diseases may occur in specific organs or throughout the body, manifest themselves in many different ways, and have different pathogenic mechanisms. At the core of autoimmune diseases is a defect in immune tolerance. Now, with the help of single-cell and spatial analyses, researchers can explore and grasp the underlying biological mechanisms of these diseases.
How we provide our clients with insights into autoimmune diseases through spatial omics
CD Genomics offers a spatial genomics technology service that performs spatial analysis of the entire transcriptome sequencing while annotating biopsy samples. It also focuses gene comparisons on tissue regions showing immune infiltration, allowing our clients to refine the list of genes associated with disease and elucidate sample differences. This will help our clients discover new possible therapeutic pathways, offering hope for the treatment of autoimmune diseases and alternative treatment options.
Our clients will also have access to these
- Single-cell gene expression profiling is used to identify previously uncharacterized subpopulations of cells with inflammation-triggered senescence features.
- Cellular features unique to the patient are identified using sequencing. This includes inflammatory macrophages, IgG plasma cells, and highly activated T cells.
- Use spatial transcriptome analysis to reveal the complexity of the immune population in diseased organs and monitor gene expression within tissues.
- Use smFISH in combination with single-cell transcriptome analysis to generate a detailed picture of pathological tissue processes.
Sample requirements
Spatial transcriptomic or proteomic analysis can be performed on freshly frozen and formalin-fixed tissues.
- The use of frozen tissue requires the collection of specialized biopsy tissues.
- The use of formalin-fixed tissue facilitates retrospective studies from diagnostic biobanks and allows for histological evaluation of the same biopsy tissue.
Practical applications in disease treatment areas
We do it better
CD Genomics maps spatially resolved gene expression data onto high-resolution histological images, which can guide our clients in understanding the pathological, physiological mechanisms of different autoimmune diseases. This of course includes resolving the manifestations of underlying, complex heterogeneous autoimmune diseases and through what cell types and genetic pathways they develop. This promises to change the way autoimmune diseases are currently diagnosed and treated.
