InquiryZika virus is a mosquito-borne flavivirus, and to date, a total of 86 countries and territories have reported evidence of Zika virus infection transmitted via mosquitoes. Most people with Zika virus infection have only mild or no symptoms, and there is no treatment for Zika virus infection or its associated diseases. This suggests that we also need to strengthen regional epidemiological surveillance to address the high morbidity and morbidity/disability resulting from widespread Zika virus epidemics.
How we can detect and track the spread of the Zika virus using spatial omics
CD Genomics offers an RNA ISH assay that provides researchers with a powerful and accurate tool. The method can detect low levels of viral RNA in virtually any tissue sample. and our in situ spatial histology analysis preserves the morphology of infected tissue, thus allowing detection of viral RNA in a morphological context. this ability to detect viruses in the context of infected tissue will advance our customers' understanding of Zika virus biology.
- Decoding Zika virus-host surface group interactions.
- Report information on spatially and functionally distinct receptor abundances.
- Map the locally restricted cell surface signaling microenvironment where receptors reside, including the organization of extracellular protein networks, and the extracellular receptor-ligand interactions that are ultimately utilized in the viral life cycle.
- Combine sample preparation methods to elucidate spatially and temporally resolved surface group dynamics.
General technical flow
- Detects target RNA within intact cells and amplifies target-specific signals but does not amplify the background noise of non-specific hybridization.
- Compatible with conventional formalin-fixed, paraffin-embedded tissue specimens for bright-field microscopy using conventional chromogenic dyes, and for multiplex analysis using fluorescent dyes.
- Allows multiplex detection of multiple target genes, enabling single-molecule visualization in individual cells with high sensitivity and specificity.
We do it better
Although the number of cases of Zika virus infection has declined, it remains a significant threat due to the sporadic and unpredictable nature of outbreaks. The potential for another outbreak, coupled with devastating neurological complications, continues to require extensive research. CD Genomics provides spatial omics technology services to help clients gain insight into the detailed mechanisms of viral particle assembly to fully understand the viral pathophysiology for antiviral drug development. Designed to help our clients detect the spread of new pathogens earlier and predict disease transmission in more real-time, and even develop new effective treatments.
