InquiryResearchers have used visualization techniques such as microscopy to extensively explore the multicellular structure of tissues, the structure, and conformation of intracellular DNA, RNA, and chromatin components. This information is useful for assessing changes in gene expression and cellular function and can be correlated with disease status and progression.
How we provide genome mapping services
With the introduction of high-throughput multiplex assay platforms and thanks to the development of technologies such as fluorescence in situ hybridization (FISH), live-cell imaging, genome perturbation tools, and massively parallel sequencing, CD Genomics can now use spatial genomics technologies to map genomic information in cells and even tissues to spatial locations, enabling the preservation of some important details in cellular mechanisms, which has become a new frontier in biology and biomedical research.
The technical services provided by CD Genomics allow researchers to preserve the spatial relationships between cells and reveal the biological structure of normal and diseased tissues, thus providing information not only at the single-cell level but also at the tissue level. We can use fluorescent DNA probes in combination with super-resolution microscopy to detect transcripts of over 10,000 different genes in tissue sections at sub-cellular resolution. And these technical services are highly sensitive, capable of analyzing hundreds of thousands of cells in tissue sections simultaneously, and have already made progress in mapping gene expression.
Practical applications and advantages
Although a newcomer to the field of genomics, CD Genomics provides spatial genomic mapping for a very diverse range of applications. Spatial genome mapping can contribute to the further development of core questions in fields such as immuno-oncology, neuroscience, cardiovascular disease, and infectious disease research.
The spatial genome mapping technology service offered by CD Genomics is tissue- and species-independent, making it suitable for multiple applications on both healthy and diseased tissues. Researchers can use it to view mechanisms of tumor heterogeneity, tissue morphology, tissue development, and response to therapeutic interventions.
The multimodal genomic profiling approach offered by CD Genomics provides a versatile platform to quantify how intracellular and extracellular factors contribute to gene expression, protein abundance, and other cellular phenotypes. This approach can resolve the interactions between the immune system and tumors to understand disease progression and treatment response to help researchers understand the immune response of patients to checkpoint therapies to guide biomarker development.
